Well it all depends on your personality, family situation (meaning kids not wife/wives)etc.
We have lived in Kotobabi when we are there on holiday for 8 weeks at a time. That´s fine but since my husband is Ghanaian it can get a bit frustrating when you wake up from all the cousin´s of our kids and their friends EVERY day and you realise that you are expected to feed them and organise their transport home which means hiring a mini bus . As a single English man that would not be a problem. That´s why I am asking about your family situation (no marriage proposal )
We are planning to stay in East Legon when we are moving to Ghana. It´s calm and I can choose how many days a week I want to see the in-laws. I also want the closeness to super markets to get more independent even if our son is very suspicious of the area and the high walls. He thinks that there are no kids living there since he can´t see them.
Areas like East Legon, Airport Residential Area are quite costly though.
Our first months we will spend in Ashaley Botwe. A nice and calm area, not as expensive, with ordinary Ghanaians. Only problem is shortage of water but that can be solved with a water tank. You need one anyway since the water stops flowing at times in any tap.Some nice areas have heavy traffic so no one would like to visit you and you will have to spend hours in traffic jams.
Let me know what kind of area you´d like and how much you are prepare to spend on your living costs and I can advice you further. There are so many different areas and it all depends on who you are.